Category A - These drugs have been demonstrated not to pose any risks to human fetuses.

Category B - These drugs are believed not to pose any significant risk to human fetuses, based on what has been learned from animal or human studies.

Category C - These drugs may or may not be harmful to human fetuses. The data is inconclusive, either because no studies have been done or because any adverse effects that have been demonstrated have shown up in animal rather than human studies.

Category D - These drugs are known to pose a threat to human fetuses, but they may be Commonly found in cases where the benefits of using the drug outweighs these risks.

Category X - These drugs have been proven to cause fetal abnormalities in humans and should not be used by under any circumstances during pregnancy. (In other words, Category X drugs are FDA-approved, but they are not to be used by pregnant women.)

 

 

 

helpful resources

  • Conceive On Air Interview about Morning Sickness
  • Get Ready to Get Pregnant
  • PregnancyLibrary.com
  • FDA RATINGS FOR PRESCRIPTION DRUG USE DURING PREGNANCY; ACTIVE INGREDIENTS IN COMMON OVER-THE-COUNTER DRUG PRODUCTS

    Table of Contents | 1 | 2 | Drug Chart

     
    Jump to:
    1. Antihistamines
    2. Antibiotics/Anti-infectives
    3. Antilipemics (Cholesterol-Lowering Drugs)
    4. Cancer Drugs
    5. Muscle Relaxants
    6. Cardiovascular Drugs
    7. Central Nervous System (CNS) Drugs
    8. Anticoagulants (Blood Thinners)
    9. Diuretics
    10. Gastrointestinal Drugs
    11. Hormones
    12. Asthma Drugs-Bronchodilators
    13. Other

    Name of Drug

    FDA Risk Factor

    Possible Problems

    What You Need to Know

    A. Antihistamines

         

    Allegra (fexofenadine)

    C

    Reports of use during pregnancy are not available.

    Product too new to evaluate. Use over-the-counter product like chlorpheniramine if treatment necessary.

    Claritin (loratidine),

    Zyrtec (ceftrizine)

    B

    Reports of use during pregnancy are not available.

    Product too new to evaluate. Use over-the-counter product like chlorpheniramine if treatment necessary.

    Hismanal (astemizole)

    C

    Limited reports of use in pregnancy available.

    Product too new to evaluate. Use over-the-counter product like chlorpheniramine if treatment necessary.

    B. Antibiotics/Anti-infectives

    1. Antifungals

    Terrazol (terconazole)

    C

    No known link to birth defects.

    Use as directed by your physician for vulvo-vaginal yeast infections.

    Diflucan (fluconazole)

    C

    Possible birth defects with continuous use at higher doses.

    Should be avoided in pregnancy, if possible.

    Fulvicin (griseofulvin)

    C

    May be associated with conjoined twins.

    Avoid.

    Mycostatin (nystatin)

    oral or cream

    B

    Doesn’t appear to be linked to birth defects.

    A possible alternative to terconazole.

    2. Antimalarials

    Aralen (chloroquine)

    C

    May be responsible for various birth defects. Research inconclusive.

    A safer alternative than quinine.

    Paludrine (proguanil)

    B

    Doesn’t appear to be linked to birth defects.

    May be best choice for malaria prophylaxis in pregnancy.

    Quinine

    D

    Possible birth defects.

    Use alternatives if possible.

    3. Antituberculosis

    Isoniazid (INH)

    C

    Toxic in animal embryos; may cause neurological abnormalities.

    Use only as directed by your physician.

    Myambutol (ethambutol)

    B

    Doesn’t appear to be linked to birth defects.

    Use only as directed by your physician.

    Rifampin

    (antituberculosis)

    C

    Possible increase in fetal anomalies.

    Use only as directed by your physician.

    4. Antivirals

    Famvir (famciclovir)

    B

    Reports of use during pregnancy are not available.

    For treatment of genital herpes. Avoid use during pregnancy, if possible.

    Retrovir (zidovudine-AZT)

    C

    Doesn’t appear to be linked to birth defects.

    Effective in preventing maternal-fetal transmission of HIV.

    Valtrex (valcyclovir)

    B

    Reports of use during pregnancy are not available.

    For treatment of genital herpes. Avoid use during pregnancy, if possible.

    Zovirax (acyclovir)

    B

    Reports of use during pregnancy are not available.

    For treatment of genital herpes. Avoid use during pregnancy, if possible. Recent evidence suggests it may be warranted in certain situations.

    5. Cephalosporins

    Keflex (cephalexin),

    Ceclor(cefaclor),

    Duricef (cefadroxil),

    Suprax (cefixime)

    B

    Doesn’t appear to be linked to birth defects.

    Use only as directed by your physician.

    6. Quinolones

    Cipro (ciprofloxacin)

    Floxin (ofloxacin)

    C

    Doesn’t appear to be linked to birth defects.

    Should be avoided in pregnancy unless no safer alternatives exist.

    NegGram (nalidixic acid)

    C

    Causes birth defects in animals.

    Should be avoided in pregnancy unless no safer alternatives exist.

    Noroxin (norfloxacin)

    C

    May be associated with birth defects.

    Should be avoided in pregnancy unless no safer alternatives exist.

    7. Penicillins

    Amoxicillin, ampicillin, cloxacillin, dicloxacillin, penicillin

    B

     

    Use only as directed by your physician.

    8. Sulfonamides (Sulfa Drugs)

    Bactrim, Septra

    (sulfamethoxazole)

    B

    May be associated with birth defects. Not confirmed. If administered near term, may cause neonatal jaundice.

    Use only as directed by your physician.

    9. Antitrichomonas

    Flagyl, Protostat

    (metronidazole)

    B

    Controversy regarding safety during pregnancy.

    Should be avoided in first trimester and used only if absolutely necessary in second and third trimesters.

    10. Urinary Antibiotics

    Macrodantin/Macrobid

    (nitrofurantoin)

    B

    Doesn’t appear to be linked to birth defects.

    Avoid using near term or with suspected G6PD deficiency (a genetic disorder that weakens red blood cells).

    Monurol (fosfomycin)

    B

    Reports of use during pregnancy are not available.

    Taken as a single dose.

    11. Scabicides/Pediculocides (Anti-lice and Scabies)

    Kwell (lindane shampoo)

    B

    May be associated with nerve damage and anemia.

    Use pyrethrins with piperonyl butoxide for lice infestations in pregnancy. See over-the-counter medication chart.

    12. Other

    Augmentin (clavulonate/amoxicillin)

    B

    May be associated with spina bifida. Not confirmed.

    Use only as directed by your physician.

    Betadine (povidone—iodine)

    D

    Prolonged use or use near term may cause fetal thyroid disorder.

    Use only as directed by your physician.

    Betasept, Hibiclens (chlorhexidine gluconate)

    B

    Doesn’t appear to be linked to birth defects.

    Used as a presurgical skin cleanser.

    Biaxin (clarithromycin)

    B

    Doesn’t appear to be linked to birth defects.

    Related to erythromycin, but newer.

    Cleocin (clindamycin)

    B

    Doesn’t appear to be linked to birth defects.

    Use only as directed by your physician.

    Erythromycin

    B

    Doesn’t appear to be linked to birth defects. Possible maternal liver toxicity with certain forms (estolate or ethylsuccinate esters).

    Preferred drug in pregnancy for chlamydia.

    pHisoHex (hexachlorophene)

    C

    Causes birth defects in animals in high doses.

    Avoid in pregnancy, especially on mucous membranes or injured skin.

    Vibramycin, Doryx (doxycycline), Minocin (minocycline), tetracycline

    D

    May cause various birth defects, tooth discoloration, and possible bone damage.

    Avoid during pregnancy.

    Zithromax (azithromycin)

    B

    Doesn’t appear to be linked to birth defects.

    Related to erythromycin, but newer.

    C. Antilipemics (Cholesterol-Lowering Drugs)

    Lipitor (atorvastatin),

    Mevacor (lovastatin),

    Lescol (fluvastatin),

    Pravachol (pravastatin),

    Zocor (simvastatin)

    X

    Theoretically toxic to fetal development.

    Do not use during or prior to pregnancy.

    Lopid (gemfibrozil)

    C

    May be associated with birth defects.

    Rarely necessary during pregnancy.

    Questran

    (cholestyramine),

    Colestid (colestipol)

    B

    Doesn’t appear to be linked to birth defects.

    Has limited use during pregnancy.

    D. Cancer Drugs

    Adriamycin (doxorubicin),

    fluorouracil,

    methotrexate, Cytoxan

    (cyclophosphamide),

    Idamycin (idarubicin),

    Novantrone (mitoxantrone),

    Oncovin (vincristine),

    Platinol (cisplatin),

    Vesanoid (tretinoin Oral)

    D

    Highly toxic. Multiple birth defects, neonatal bone-marrow suppression, and intrauterine growth restriction.

    Benefits must clearly outweigh the risks. Occupational exposure to these agents by pregnant women is potentially toxic in the first trimester.

    Novadex (tamoxifen)

    D

    Toxic in animal studies. Possibly carcinogenic as well.

    Avoid in pregnancy and for at least two months before conceiving.

    E. Muscle Relaxants

    Flexeril (cyclobenzaprine)

    B

     

    Use only as directed by your physician.

    Parafon Forte (chlorzoxazone),

    Robaxin (methocarbamol),

    Norflex (orphenadrine)

    C

    Doesn’t appear to be linked to birth defects.

    Avoid during pregnancy.

    F. Cardiovascular Drugs

    1. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)

    Capoten (captopril),

    Vasotec (enalopril),

    Zestril (lisinopril)

    D

    Toxic to fetus. Causes birth defects even in second and third trimesters.

    Avoid during pregnancy.

    2. Antihypertensives (Blood Pressure Medications)

    Aldomet (methyldopa)

    C

    Doesn’t appear to be linked to birth defects.

    Discuss switching from your current antihypertensive to methyldopa or labetalol with your caregiver.

    Inderal (propranolol)

    C

    Decreased heart rate, low blood sugar, possible growth restriction.

    Consider switching to methyldopa or labetalol.

    Lopressor (metoprolol)

    C

    First-trimester reports lacking; mild neonatal hypotension and decreased heart rate a possibility.

    Consider switching to methyldopa or labetalol.

    Normodyne (labetalol)

    C

    First-trimester reports lacking; mild neonatal hypotension and decreased heart rate a possibility.

    Preferred to methyldopa by some maternal-fetal medicine specialists.

    Tenormin (atenolol)

    C

    May be associated with birth defects. Otherwise similar to labetalol.

    Consider switching to methyldopa or labetalol.

    3. Calcium Channel Blockers

    Calan (verapaml),

    Norvasc (amlopidine),

    Procardia (nifedipine)

    C

    Not proven to be safe during pregnancy. Possible temporary fetal/neonatal cardiovascular functional abnormalities.

    Consult your cardiologist.

    4. Cardiac Drugs

    Lanoxin (digoxin)

    C

    Maternal overdose may be toxic to developing baby.

    Consult your cardiologist.

    5. Vasodilators

    Nitroglycerin

    B

    Doesn’t appear to be linked to birth defects.

    Also used for treatment of excessive uterine contractions/premature labor.

    G. Central Nervous System (CNS) Drugs

    1. Analgesics (Pain Relievers)

    Darvon, Darvocet (propoxyphene)

    C

     

    D

    May be associated with multiple birth defects. Not confirmed.

    Neonatal withdrawal symptoms if used for prolonged periods.

    Narcotic analgesics are generally preferred for occasional use in pregnancy when acetominophen is not effective.

    2. Anticonvulsants (Epilepsy Drugs)

    Depakene (valproic acid), Depakote (sodium valproate)

    D

    High incidence of cranial, facial, and limb defects, including cleft lip and palate, and underdeveloped fingers. Impaired physical and mental development, congenital heart defects.

    Untreated epilepsy poses a greater risk than valproic acid. The minimum effective dosage should be used.

    Dilantin (phenytoin, diphenylhydantoin)

    D

    Fetal Dilantin syndrome. (High incidence (2%-26%) of cranial, facial, and limb defects, including cleft lip and palate, and underdeveloped fingers. Impaired physical and mental development, congenital heart defects.

    Untreated epilepsy poses a greater risk than phenytoin. The minimum effective dosage should be used.

    Mysoline (primodone)

    D

    High association with birth defects.

    Untreated epilepsy poses a greater risk than primidone. The minimum effective dosage should be used.

    Phenobarbital

    D

    Barbiturates cross the placenta and are stored in higher concentrations in the fetus than in the mother. Possible effects include fetal addiction, fetal bleeding and coagulation defects, and possible malformations.

    Avoid except in cases in which seizure disorders can’t be treated with safer medications.

    Tegretol (carbamazepine)

    C

    Possible birth defects.

    Preferred drug for grand mal seizures. Discuss medication strategy with your neurologist.

    Zarontin (ethosuximide)

    C

    Possible birth defects.

    Preferred drug for petit mal epilepsy, especially during first trimester.

    3. Antidepressants

    Effexor (venlafaxine)

    C

    Limited reports of use during pregnancy available

    Unrelated to other antidepressants.

    Luvox (fluvoxamine)

    C

    Reports of use during pregnancy are not available.

    A selective seritonin re-uptake inhibitor (SSRI) used to treat obsessive-compulsive disorder (OCD).

    Paxil (paroxetine)

    B

    Limited reports of use during pregnancy available.

    An SSRI.

    Prozac (fluoxetine)

    B

    Limited reports of use during pregnancy available.

    Because there is longer follow-up data for this drug than for newer SSRIs, this is probably the best choice of antidepressant for use during pregnancy.

    Remeron (mirtazapine)

    C

    Reports of use during pregnancy are not available.

    A tetracyclic antidepressant chemically unrelated to tricyclics, SSRIs, and monamine oxidase (MAO) inhibitors.

    Serzone (nefazodone)

    C

    Reports of use during pregnancy are not available.

    An SSRI.

    Sinequan (doxepin)

    C

    May be associated with birth defects.

    When antidepressants are needed in pregnancy, the SSRI drugs appear to be the safest.

    Tricyclics including Elavil (amitriptyline),

    Surmontil (trimipramine),

    Tofranil (imipramine)

    D

    Possible facial, head, limb and central nervous system defects; possible neonatal withdrawal symptoms.

    Avoid in pregnancy if possible.

    Wellbutrin (bupropion)

    B

    Reports of use during pregnancy are not available.

    Mechanism of action unrelated to other antidepressants.

    Zoloft (sertraline)

    B

    Reports of use during pregnancy are not available.

    An SSRI.

    4. Narcotic Analgesics

    Codeine

    C

     

    D

    May be associated with multiple birth defects. Not confirmed.

    If used for prolonged periods or in high doses at term.

    Use only as directed by your physician.

    Dilaudid (hydromorphone),

    OxyContin, Percodan,

    Tylox, (oxycodone),

    Synalgos-DC (dihydrocodeine),

    Vicodin, Lortab (hydrocodone)

    B

    D.

    Reports of use during pregnancy are not available.

    If used for prolonged periods or in high doses at term.

    Use only as directed by your physician.

    Demerol (meperidine)

    B

    D

    May be associated with hernias.

    If used for prolonged periods or in high doses near term, baby may experience withdrawal, respiratory depression, growth restriction and neonatal death.

    Use only as directed by your physician.

    Heroin (diacetylmorphine)

    B

    D

    Possible chromosome damage. If used for prolonged periods or in high doses near term, baby may experience withdrawal, respiratory depression, growth restriction, lagging intellectual development and neonatal death.

    Do not use during pregnancy.

    Methadone

    B

    D

    If used for prolonged periods or in high doses near term, baby may experience withdrawal, respiratory depression, growth restriction, and neonatal death.

    Use only as directed for treatment of narcotic addiction.

    Morphine

    B

    D

    May be associated with hernias.

    If used for prolonged periods or in high doses near term, baby may experience withdrawal, respiratory depression, growth restriction, and neonatal death.

    Use only as directed by your physician.

    Talwin (pentazocine)

    B

    D

    If used for prolonged periods or in high doses near term, baby may experience withdrawal, respiratory depression, growth restriction, and neonatal death.

    Use only as directed by your physician.

    Ultram (tramadol)

    C

    Possibly toxic in animals at high doses-related to codeine but not addictive.

    Too new to recommend over traditional narcotic pain-relievers.

    5. Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

    Anaprox (naproxen)

    B

    Doesn’t appear to be linked to birth defects.

    Should not be used by women trying to conceive. May impair implantation.

    Ansaid (flurbiprofen),

    Clinoril (sulindac),

    Motrin (ibuprofen),

    Ponstel (mefenamic acid),

    Voltaren (diclofenac)

    D

    If used during the third trimester or near delivery, this drug can cause neonatal pulmonary hypertension.

    Should not be used by women trying to conceive. May impair implantation.

    Relafen (nabumetone),

    Daypro (oxaprozin)

    C

    D

    Doesn’t appear to be linked to birth defects.

    If used during the third trimester or near delivery, this drug can cause neonatal pulmonary hypertension.

    Should not be used by women trying to conceive. May impair implantation.

    6. Sedatives and Hypnotics

    Ambien (zolpidem)

    B

    Reports of use during pregnancy are not available.

    Relatively new, so if sleeping pill is absolutely needed, most doctors will prescribe a barbiturate, narcotic, or antihistamine for occasional use only.

    Benzodiazepines such as Valium (diazepam),

    Xanax (alprazolam),

    Klonipin (clonazepam)

    Ativan (lorazepam)

    D

    Possible birth defects, neonatal depression, "floppy baby" syndrome, neonatal withdrawal.

    Avoid, especially in first trimester. Severe panic disorders may need to be treated in the second and third trimesters.

    7. Stimulants/Appetite Suppresants

    Fastin, Adipex-P (phentermine)

    C

    May be associated with stillbirth.

    Avoid during pregnancy and preconceptionally.

    Meridia (sibutramine)

    C

    Causes birth defects in animals at higher doses.

    Avoid during pregnancy.

    8. Tranquilizers

    Lithium

    D

    Possible changes in newborn heart rhythms and thyroid function; possible goiter, jaundice, electrolyte imbalance. Possible birth defects, especially of the heart.

    Avoid during pregnancy.

    Phenothiazines such as

    Trilafon (perphenazine),

    Compazine (prochlorperazine),

    Fluphenazine

    C

    Research regarding birth defects is inconclusive. Possible neurological effects on fetus when taken close to term.

    Avoid using these drugs near term. It may be safe to use some of these drugs for the treatment of severe nausea and vomiting in the first trimester.

    H. Anticoagulants (Blood Thinners)

    Coumadin (warfarin)

    D

    High incidence of birth defects (for example, "Fetal warfarin syndrome"); may lead to fetal hemorrhage or death.

    Do not use these drugs during pregnancy. Heparin is the drug of choice when anticoagulation is necessary.

    Heparin

    C

    Fetal and maternal complications possible with prolonged use.

    Generally preferable to Coumadin (warfarin) when anticoagulation is needed in pregnancy.

    I. Diuretics

    Lasix (furosemide)

    C

    Possible electrolyte imbalance, increased fetal urine output.

    Should be used only in cases of severe hypertension and other cardiovascular disorders.

    Thiazides such as

    Dyazide, Maxzide,

    Aldactazide (hydrochlorthiazide),

    Diuril (chlorothiazide)

    D

    Bone-marrow depression, possible birth defects, decreased platelet count (poor blood clotting), electrolyte imbalance.

    Should be used only in cases of severe hypertension and other cardiovascular disorders.

    J. Gastrointestinal Drugs

    1. Antidiarrheal

    Immodium (loperamide)

    B

    Doesn’t appear to be linked to birth defects.

    Use only as directed by your physician.

    Lomotil (diphenoxylate)

    C

    Doesn’t appear to be linked to birth defects.

    Related to narcotic meperidine. (Demerol).

    2. Anti-emetics (Antinausea)

    Phenergan (promethazine),

    Tigan (trimethobenzamide),

    Compazine (prochlorperazine)

    C

    Doesn’t appear to be linked to birth defects. Frequent use in later part of pregnancy may be associated with neonatal jaundice, depression and withdrawal symptoms.

    An option for severe morning sickness (hyperemesis gravidarum).

    Reglan (metoclopramide)

    B

    Doesn’t appear to be linked to birth defects.

    Also used when needed to stimulate breast milk production in nursing mothers.

    3. Antisecretory Drugs

    Cytotec (misoprostil)

    X

    Causes miscarriage and birth defects.

    Do not use during pregnancy.

    Pepcid (famotidine)

    B

    Reports of use during pregnancy are not available.

    Use only as directed by your physician.

    Prilosec (omeprazole)

    C

    No birth defects in animals, but effects unclear in humans.

    Avoid during pregnancy, especially prior to week 20.

    Prevacid (lansoprazole)

    B

    Reports of use during pregnancy are not available.

    Structurally similar to omeprazole. Avoid during pregnancy, especially prior to week 20.

    Zantac (ranitidine)

    B

    Doesn’t appear to be linked to birth defects.

    Use only as directed by your physician.

    K. Hormones

    1. Adrenal

    Cortisone, Hydrocortisone (forms other than topical)

    D

    Possible birth defects. Possible neonatal adrenal suppression and electrolyte imbalance.

    Switch to prednisone if necessary.

    Dexamethasone

    C

    Birth defects in animals; no observed birth defects in humans. Possible neonatal adrenal suppression and electrolyte imbalance.

    Switch to prednisone if necessary.

    Prednisone

    B

    Doesn’t appear to be linked to birth defects. Possible neonatal adrenal suppression and electrolyte imbalance.

    Preferred adrenal steroid during pregnancy. Should be used instead of other corticosteroids whenever possible.

    2. Antidiabetic Drugs

    Diabinase (chlorpropamide)

    D

    Suspected birth defects, low blood sugar, fetal death.

    Change to insulin if your diabetes cannot be controlled by diet alone.

    Glucophage (metformin)

    B

    Appears to be the safest of the oral diabetes drugs.

    Though insulin is the drug of choice for the treatment of diabetes during pregnancy, this drug may be preferred for women of childbearing age who are not planning a pregnancy.

    Glucotrol (glipizide)

    C

    Doesn’t appear to be linked to birth defects.

    Change to insulin if your diabetes cannot be controlled by diet alone.

    Glynase (glyburide)

    D

    Possible birth defects with first trimester use.

    Change to insulin if your diabetes cannot be controlled by diet alone.

    Insulin

    B

    Low blood sugar. Maternal insulin shock can result in fetal death.

    Your dose may have to be adjusted during pregnancy. Consult your physician.

    Orinase (tolbutamide)

    D

    Possible birth defects, low fetal platelet count, low blood sugar, fetal death.

    Change to insulin if your diabetes cannot be controlled by diet alone.

    3. Antiprogesterone Drugs

    RU486 (mifepristone)

    X

    Causes abortion.

    Do not use during pregnancy.

    4. Antithyroid

    Propylthiouracil (PTU),

    Tapazole (methimazole)

    D

    May cause various birth defects and fetal/neonatal hypothyroidism.

    PTU is the drug of choice for treatment of hyperthyroidism during pregnancy.

    Radioactive Iodine

    X

    Causes birth defects.

    Do not use during pregnancy.

    5. Estrogens

    Clomid, Serophene(clomiphene)

    X

    Though rated X by manufacturer, no birth defects are proven.

    A fertility drug. Should be used only after possibility of pregnancy has been ruled out.

    DES (diethylstilbestrol)

    X

    Reproductive organ defects and future reproductive problems.

    Should not be used during pregnancy.

    Oral contraceptives including the morning-after pill (contain estrogen and/or progestogen)

    X

    Possible genital anomalies like with DES. Possible advanced neonatal bone age with resulting short stature.

    Stop taking your oral contraceptives as soon as pregnancy is confirmed. (You should take a pregnancy test as soon as possible if you suspect that you may be pregnant.)

    6. Progestogens

    Crinone, Prometrium, Micronized progesterone (progesterone)

    Not Rated

    No animal reports and Doesn’t appear to be linked to birth defects.

    Used for the treatment of infertility, luteal phase deficiency, and assisted reproductive technologies in first 10 weeks of pregnancy.

    Provera (medroxyprogesterone)

    D

    Possible birth defects.

    When used to treat abnormalities or absence of menstruation, pregnancy must be ruled out first.

    7. Thyroid

    Synthroid (levothyroxine), Armour thyroid (thyroid hormones)

    A

    No adverse effects with appropriate doses.

    Use only as directed by your physician. Dose may need to be adjusted during pregnancy.

    L. Asthma Drugs-Bronchodilators

    1. Sympthomimetics

         

    Alupent (metaproterenol),

    Max air (pirbuterol),

    Ventolin, Proventil (albuterol), Serevent (salmeterol)

    C

    No apparent link to birth defects in normal inhaled doses.

    Generally available as inhalers. Use as directed by your physician in minimum effective doses.

    2. Antispasmodics

    Aminophyllin, TheoDur (theophyllin)

    C

    May be associated with birth defects.

    One of a number of acceptable treatments for chronic asthma during pregnancy.

    M. Other

    1. Acne

    Accutane (isotretinoin)

    X

    Increased risk of miscarriage and birth defects.

    Stop using the drug at least one month prior to attempting pregnancy.

    Retin-A (tretinoin)

    C

    No proven adverse effects when used topically.

    Not to be confused with Accutane (above) or cancer drug Vesanoid (tretinoin oral).

    2. Antimigraine

    Amerge (naratriptan)

    C

    Possibly toxic in animals at higher doses.

    Limited reports in human pregnancy-avoid in pregnancy.

    Imitrex (sumatriptan)

    C

    No apparent link to birth defects, but data lacking. Possible increase in risk of miscarriage.

    Avoid in pregnancy.

    Midrin (isometheptene)

    C

    Reports of use during pregnancy are not available.

    Use only as directed by your physician.

    3. Urinary Tract Antispasmodics

    Cystospaz (flavoxate)

    B

    Reports of use during pregnancy are not available.

    Avoid in pregnancy.

    Detrol (tolterodine tartrate)

    C

    Possibly toxic in animal pregnancies at high doses.

    Avoid in pregnancy.

    Ditropan (oxybutynin)

    B

    Reports of use during pregnancy are not available.

    Avoid in pregnancy.

    Urospaz (l-hyoscyamine)

    C

    May be associated with birth defects.

    Avoid in pregnancy.

    4. Weight Loss/Fat Blocking

    Xenical (orlistat)

    B

    Reports of use during pregnancy are not available.

    Avoid in pregnancy.

    Note: Some drugs have more than one rating. This is because they may be more dangerous at stages of pregnancy, in certain dosages, or in combination with other drugs. This information should not be considered medical advice. It is provided as background information only. Only your physician, who knows you and your medical history, can provide you with advice about taking medications. Consult your health care provider for information about the most recent information about the safety of various prescription medications during pregnancy or consult The March of Dimes, The Motherisk Clinic, or another reliable source of healthcare information. For leads on other healthcare associations, see PregnancyLibrary.com.

    Original material based on the latest data available as of December 1999. Reference material includes The Unofficial Guide to Having A Baby by Ann Douglas and John R. Sussman, M.D. New York: IDG Books, 1999. Before You Conceive by John R. Sussman, M.D., and B. Blake Levitt. New York: Bantam Books, 1989. Drugs in Pregnancy and Lactation (fifth edition, 1998) by Gerald G. Briggs, Roger K. Freeman, and Sumner J. Taffe. Baltimore: Williams and Wilkins, 1998. (Plus updates Volume 11 Number 2, June 1998 through Volume 12 Number 3, September 1999). Physician's Desk Reference. Oradell, NJ: Medical Economics Publishers, 1999. Drugs and Pregnancy by Larry C. Gilstrap III and Bertis B. Little. New York: Elsevier Science Publishing Co., Inc., 1992.

    For further information on medication use during pregnancy, see The Mother of All Pregnancy Books (American edition and Canadian edition), The Unofficial Guide to Having A Baby (second edition) and Trying Again: A Guide to Pregnancy After Miscarriage, Stillbirth, and Infant Loss. You may also want to check ou the articles page of this Web site for other useful information on healthy living during pregnancy.

     
    © Copyright 2000-07 Ann Douglas. All rights reserved.